Wow
Reasonably large RCT of high-dose chloroquine vs low-dose chloroquine (all patients received azithro)
At 6 days, high-dose CQ group had 17% mortality compared to 10% in the low-dose group
No benefit to high-dose CQ on lung parameters, trial stopped earlyhttps://twitter.com/BrianDunning/status/1249825311354650629 …
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Also worth noting that with no placebo control we still don't know if CQ 'works' or not for COVID-19, but we can say that higher doses don't appear to be beneficial/appear harmful which is a very important thing to know
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Do we, though? Isn't the point of small, early stage RCTs to see if it's worth moving on to larger scale studies? More people dying would seem like a pretty good sign that a larger RCT is not indicated.
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