Wow
Reasonably large RCT of high-dose chloroquine vs low-dose chloroquine (all patients received azithro)
At 6 days, high-dose CQ group had 17% mortality compared to 10% in the low-dose group
No benefit to high-dose CQ on lung parameters, trial stopped earlyhttps://twitter.com/BrianDunning/status/1249825311354650629 …
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Preprint is here. Note that this is not hydroxychloroquine, but similar method of action/similar drug https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1 …
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Replying to @GidMK
Do you think the lack of a no-chloroquine control arm is a justifiable choice?
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Replying to @bogdienache @GidMK
If one accepts that it is unethical to have a trial without an active control (I don’t but can see why some argue this) maybe, but the design of the trial in the preprint is very odd.
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The design did not plan to compare the randomized arms against one another for the primary outcome. Instead they planned to compare each one against a fixed rate derived from the “historical control” rate.
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This might be the reason. They weren't allowed to include a placebo control arm I suspectpic.twitter.com/a1CwMs4pJh
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