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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 13 Apr 2020

      Health Nerd Retweeted Brian Dunning

      Wow❗️Reasonably large RCT of high-dose chloroquine vs low-dose chloroquine (all patients received azithro) At 6 days, high-dose CQ group had 17% mortality compared to 10% in the low-dose group No benefit to high-dose CQ on lung parameters, trial stopped earlyhttps://twitter.com/BrianDunning/status/1249825311354650629 …

      Health Nerd added,

      Brian DunningVerified account @BrianDunning
      A small (n = 440) Brazillian trial of chlorquine (not hydroxychloroquine) alongside azithromycin has been halted after 20 days because the drug had no benefit for #COVID19 patients and was killing people. https://clinicaltrials.gov/ct2/show/NCT04323527 … Do. Not. Recommend. Unproven. Therapies.
      6 replies 90 retweets 191 likes
      Show this thread
      Health Nerd‏Verified account @GidMK 13 Apr 2020

      Preprint is here. Note that this is not hydroxychloroquine, but similar method of action/similar drug https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1 …

      3:40 PM - 13 Apr 2020
      • 10 Likes
      • Kurikesh George Tad 💪💉💉 fully vaccinated Felicia L Henry, BCCE, IBCLC Comrade Weez James Pitt American Emu and Volcano Lover 🌋🌋🌋 Indy🔻#BLM
      2 replies 0 retweets 10 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK 13 Apr 2020

          No benefit at day 6 in terms of COVID-19 outcomes (ICU, ventilation etc) (Also, joys of preprints, based on the results this table is labelled incorrectly - the columns are switched)pic.twitter.com/oJBuoJNH8x

          2 replies 0 retweets 9 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK 13 Apr 2020

          Also worth noting that this is a small sample (81 patients) and therefore no statistical significance as the trial was stopped early Impossible to say whether it's definitive, we still need a large RCT to know for sure

          2 replies 0 retweets 9 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK 13 Apr 2020

          Also worth noting that with no placebo control we still don't know if CQ 'works' or not for COVID-19, but we can say that higher doses don't appear to be beneficial/appear harmful which is a very important thing to know

          1 reply 0 retweets 10 likes
          Show this thread
        5. End of conversation
        1. New conversation
        2. Bogdan Enache‏ @bogdienache 13 Apr 2020
          Replying to @GidMK

          Do you think the lack of a no-chloroquine control arm is a justifiable choice?

          2 replies 0 retweets 1 like
        3. Andrew Althouse‏ @ADAlthousePhD 13 Apr 2020
          Replying to @bogdienache @GidMK

          If one accepts that it is unethical to have a trial without an active control (I don’t but can see why some argue this) maybe, but the design of the trial in the preprint is very odd.

          1 reply 1 retweet 1 like
        4. Show replies

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