Wow
Reasonably large RCT of high-dose chloroquine vs low-dose chloroquine (all patients received azithro)
At 6 days, high-dose CQ group had 17% mortality compared to 10% in the low-dose group
No benefit to high-dose CQ on lung parameters, trial stopped earlyhttps://twitter.com/BrianDunning/status/1249825311354650629 …
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No benefit at day 6 in terms of COVID-19 outcomes (ICU, ventilation etc) (Also, joys of preprints, based on the results this table is labelled incorrectly - the columns are switched)pic.twitter.com/oJBuoJNH8x
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Also worth noting that this is a small sample (81 patients) and therefore no statistical significance as the trial was stopped early Impossible to say whether it's definitive, we still need a large RCT to know for sure
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Also worth noting that with no placebo control we still don't know if CQ 'works' or not for COVID-19, but we can say that higher doses don't appear to be beneficial/appear harmful which is a very important thing to know
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Do you think the lack of a no-chloroquine control arm is a justifiable choice?
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If one accepts that it is unethical to have a trial without an active control (I don’t but can see why some argue this) maybe, but the design of the trial in the preprint is very odd.
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