Preprint is here. Note that this is not hydroxychloroquine, but similar method of action/similar drug https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1 …
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No benefit at day 6 in terms of COVID-19 outcomes (ICU, ventilation etc) (Also, joys of preprints, based on the results this table is labelled incorrectly - the columns are switched)pic.twitter.com/oJBuoJNH8x
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Also worth noting that this is a small sample (81 patients) and therefore no statistical significance as the trial was stopped early Impossible to say whether it's definitive, we still need a large RCT to know for sure
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Also worth noting that with no placebo control we still don't know if CQ 'works' or not for COVID-19, but we can say that higher doses don't appear to be beneficial/appear harmful which is a very important thing to know
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Poke
@Damkyan_Omega si tu as pas encore vuThanks. Twitter will use this to make your timeline better. UndoUndo
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So they only stopped the high dose arm per preprint? Also, only compared with hx controls for no tx , no placebo arm. I agree that we shouldn’t jump on HCQ bandwagon, but would like more definitive data. But appears that all this showed was a trend towards >tox in high dose?
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Pretty much. According to preprint, CQ/HCQ was mandated as a treatment at a federal level in Brazil, so both arms had to receive it. Higher dose appeared to be dying more so trial halted early
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The stimulus money will actually be paid out in hydroxychloroquine tablets
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They also had to have one of eight comorbidities for inclusion. Patients were included with or without a confirmatory diagnosis of SARS-CoV-2. They were also given oseltamivir if influenza was suspected. Some of the patients were intubated. What a mess.
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Reasonably large RCT of high-dose chloroquine vs low-dose chloroquine (all patients received azithro)
At 6 days, high-dose CQ group had 17% mortality compared to 10% in the low-dose group
No benefit to high-dose CQ on lung parameters, trial stopped early