The paragraph also isn't good news for the study's rigor Of 61 total patients, 8 were excluded because of missing information Of the remaining 53, only 40 received the full course of the drug
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Worth pointing out at this point that there's NO CONTROL GROUP That's a huge problem for inference - how do we know if any improvement seen in this trial had anything to do with the drug?
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On to the patient demographics It's a relatively young, although fairly unhealthy population About what you'd expect given the inclusion criteria (although a bit younger perhaps)pic.twitter.com/TKCQ04GwFC
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And here we get to the main results Of the patients (53) treated with remsevidir, most improved! The death rate also appears to have been pretty low at only 13% (7/53)pic.twitter.com/8VogvKfDxU
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Remember, these were VERY sick people. In groups admitted to an ICU for
#COVID19, the median death rate is usually around 30%2 replies 1 retweet 11 likesShow this thread -
The authors have constructed an arbitrary ordinal scale here from 1-6, where 6 is the worst (death) and 1 is the best (discharged) Based on this scale, most patients improved on remdesivirpic.twitter.com/UtcUDlTvzX
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HOWEVER, there was a huge issue here Most patients didn't have the follow-up required to perform this calculation. In fact, based on the IQR presented here, less than 25% had 28 days follow-up data to analyze!pic.twitter.com/asI1gDSlEV
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Younger people did better than older, people who were not mechanically ventilated did better than those who were (not surprising perhaps)pic.twitter.com/2gHltBjWHt
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There were also a large number of reported side-effects, although given the lack of a control group and how sick these people were it's very hard to know if they had anything to do with remdesivirpic.twitter.com/9YS5cmlhxm
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And then perhaps the HCQ and azithro combo would cause arrhythmia, the remdisivir would cause liver damage (fairly common side-effects), and you'd end up in ED with multi-organ issues, and with no benefit to the original infection 

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