Remember, these were VERY sick people. In groups admitted to an ICU for #COVID19, the median death rate is usually around 30%
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Basically, it was a very small study with HUGE caveats that showed an interesting possibility Hard to say anything more than that without a proper trial of some kind
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Some might argue that this should not have been published as a research trial, given the many caveats and huge conflicts of interest this study seems to contain I guess that's a question for
@NEJM, who appear to have garnered millions of reads on the article in the last few daysShow this thread
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There are guidelines if you want to provide an 'official' grade for limitations.https://www.jclinepi.com/article/S0895-4356(10)00413-0/fulltext …
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Dunno if GRADE would be that useful here tho, it'd be high risk of bias for every element lol
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We teach students how to read scientific papers. What you just did is the worst way to do it. The authors obviously did not design the study to happen as it did- they took advantage of a situation as it unfolded. Of course things are not perfect (controls, etc). (next...)
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Let's sum up. Your criticism of this paper was too long, too repetitive and missed the only point it could have made. Retrospectively, you should have just posted the link and kept your stream of consciousness to yourself.
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Much easier to bash a study than try to learn something from it. There is value in this paper.
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The UK is addressing misinformation by launching an independent service. https://twitter.com/thehouselive/status/1248243329663287297?s=21 …https://twitter.com/TheHouseMag/status/1248243329663287297 …
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very small retrospective trial
no causal conclusions!