On to the patient demographics It's a relatively young, although fairly unhealthy population About what you'd expect given the inclusion criteria (although a bit younger perhaps)pic.twitter.com/TKCQ04GwFC
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To the author's credit, the final paragraph acknowledges most of this!pic.twitter.com/0TdO2drS1C
Let's sum up:
very small retrospective trial
no control group
written by pharma funder
high dropout
short timeframe
missing data
poorly written/edited
somewhat odd stats
highly selected patient cohort
no causal conclusions!
Basically, it was a very small study with HUGE caveats that showed an interesting possibility Hard to say anything more than that without a proper trial of some kind
Some might argue that this should not have been published as a research trial, given the many caveats and huge conflicts of interest this study seems to contain
I guess that's a question for @NEJM, who appear to have garnered millions of reads on the article in the last few days
Ah so here is the one reasonable criticism you should have made and you still screwed it up. The compassionate use of #remdesivir was applied for. This could have led Gilead to select for the best candidates and should have been presented.
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