Worth pointing out at this point that there's NO CONTROL GROUP That's a huge problem for inference - how do we know if any improvement seen in this trial had anything to do with the drug?
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We also have very few patients in this trial, and no control group Also, the patients were selected by their doctors - perhaps picking the patients that they thought had a fighting chance? We can't really say whether the death rate was low or high from the data we have!
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To the author's credit, the final paragraph acknowledges most of this!pic.twitter.com/0TdO2drS1C
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Let's sum up:
very small retrospective trial
no control group
written by pharma funder
high dropout
short timeframe
missing data
poorly written/edited
somewhat odd stats
highly selected patient cohort
no causal conclusions!Show this thread -
Basically, it was a very small study with HUGE caveats that showed an interesting possibility Hard to say anything more than that without a proper trial of some kind
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Some might argue that this should not have been published as a research trial, given the many caveats and huge conflicts of interest this study seems to contain I guess that's a question for
@NEJM, who appear to have garnered millions of reads on the article in the last few daysShow this thread
End of conversation
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