When not published, the product just disappears never to be seen again. Not spending money on something that doesn’t work.
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(Top) pharma companies are nowadays more likely to publish results (whether positive or negative) due to obligations to register protocols and report study results
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My employer, a medium size pharmaco, has SOPs in place (for >10 years) that all studies MUST be published. However, it does not require (and it would not be feasible) to publish failed studies in high impact journals.
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