I restate my request: I'd like to see placebo-controlled trials of select individuals who report very strong responses to supplement regimens that are not currently shown to be efficacious in large trials.https://twitter.com/undarkmag/status/1228907122945032192 …
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Replying to @AlanLevinovitz
There have been for some things. MSG springs to mind, although obviously that's a negative effect, but they recruited people who reported strong effects to test the theory on
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Replying to @GidMK @AlanLevinovitz
Most studies on non gluten sensitivity is on people who themselves are convinced that they react badly to gluten There are also studies on people who are sure they get headaches from aspartame
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Replying to @JacobGudiol @GidMK
Yes, I know about both of these, although I favor supplements b/c they are easier to control than dietary trials (fewer confounders). But gluten is a good example: seems small % have NCGS...
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Replying to @AlanLevinovitz @GidMK
I'm not convinced about gluten and NCGS. Maybe there's something else in wheat like fructans though With aspartame the results are negative https://www.ncbi.nlm.nih.gov/pubmed/25786106
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Replying to @JacobGudiol @GidMK
Yeah, I'm also not entirely sure about NCGS, but definitely open to it...as for aspartame I don't know the studies, but not surprised. Either way, I think the supplement version of these would be much cleaner.
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The challenge is, with both scenarios, that people's self-reported reactions to things aren't very reliable. Ideally you'd want to find people who had an objectively large reaction to test it on for the design you have in mind
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