It’s a bit of an odd one. All the people are well below the age of an average stroke victim. I’d be interested to see how many cases there actually were.
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Replying to @cjsnowdon
This is true, which is why the absolute risk difference is very small. All of the prevalence data is in Table 1, in total there appear to have been about 1,300 strokes in the sample (of ~161,000)pic.twitter.com/yypKrgYIIE
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Replying to @GidMK @cjsnowdon
That being said, there were sufficient numbers for statistical purposes, I'd say the bigger issue is that the study was cross-sectional so hard to make causal inferences here
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Replying to @GidMK
It’s surprising that the ex-smokers didn’t see their risk fall by more.
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Replying to @cjsnowdon
Dunno, the adjusted odds ratio was 0.43, so a relative drop of 57%. You'd expect to see the absolute figures increase as the population ages I would say that these figures are the only ones that are a bit iffy, there weren't many sole vapers in the sample
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Replying to @GidMK @cjsnowdon
You can see what I mean in the confidence interval here - the benefit could be as big as an almost total reduction in risk or as small as a miniscule effectpic.twitter.com/DAsevTDMiM
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Replying to @GidMK @cjsnowdon
Tbh, the same is actually true of the issues with dual use, the confidence interval ranges from a tiny harm to a massive onepic.twitter.com/LLeJsCnUu5
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Replying to @GidMK
I was thinking more about this.pic.twitter.com/ha3gjkiK6o
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Replying to @cjsnowdon
Hard to know what that means considering it's cross-sectional tho. Could be a simple case of confounding - people who had strokes switched to vaping, so when you take a single snapshot you see an increased risk
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Replying to @GidMK
That’s John Britton’s view. Cross-sectional studies with ex-smoking vapers have huge and obvious problems. https://www.sciencemediacentre.org/expert-reaction-to-study-on-smoking-vaping-and-stroke-risk/ …
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Mmmm, definitely don't agree with everything he's said there, but generally he's correct. Reverse causation is probably the biggest issue here
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