Skip to content
By using Twitter’s services you agree to our Cookies Use. We and our partners operate globally and use cookies, including for analytics, personalisation, and ads.
  • Home Home Home, current page.
  • About

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

Tweets

Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

Tweets

  • © 2021 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    1. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      The metabolism of many #polyphenols is superbly described by @phisquarelab @anarmateos @Prof_JPESpencer in their outstanding review (https://www.ncbi.nlm.nih.gov/pubmed/22794138 ) - showing that what could act as antioxidant quickly disappears, courtesy of metabolising enzymes.pic.twitter.com/iOaEbH4h6Z

      1 reply 1 retweet 13 likes
      Show this thread
    2. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      A detailed study of one particular #polyphenol, the #flavanol #epicatechin showed that there is virtually no pure compound in circulation - only metabolites. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929566/ …pic.twitter.com/QO7udXUzUE

      1 reply 1 retweet 9 likes
      Show this thread
    3. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      So they are not #antioxidants in vivo - and there are huge differences in metabolism between humans and animals, making data from animal studies rather unreliable. Even cell-culture studies are difficult to conduct as for most compounds, metabolites are not easily available.pic.twitter.com/EbpJP3POFm

      1 reply 0 retweets 4 likes
      Show this thread
    4. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      What about human studies? There are many intervention studies that report a beneficial effect of #polyphenols - but it is important to distinguish between food and compound. An apple is primarily an apple - not just plain packaging for #flavanols.pic.twitter.com/cwNZmqx5jt

      1 reply 1 retweet 8 likes
      Show this thread
    5. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      The same applies to tea, berries or chocolate - they are primarily foods. It is difficult to obtain pure compounds, so foods are often used as alternative - but one has to be careful to extrapolate the effect of pure compounds.

      1 reply 1 retweet 8 likes
      Show this thread
    6. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      The same problem applies to population studies - they usually have to rely on dietary data to estimate intake of compounds, and there is again a difference between a glass of Argentinian Malbec and pure resveratrol, or an Apple and pure epicatechin.pic.twitter.com/PBVrOOdp6P

      1 reply 0 retweets 6 likes
      Show this thread
    7. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      Results from observational studies are actually quite weak - for example for flavanol, they do not show an overall clinically significant effect in either direction.pic.twitter.com/PRU653bqRZ

      1 reply 0 retweets 5 likes
      Show this thread
    8. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      Thus it is very difficult to differentiate between the effect of #polyphenols in the diet - and the dietary pattern that provides polyphenols. The latter is undoubtedly healthy, as it includes a large variety of fruits and vegetables.pic.twitter.com/2dv31aDnz1

      1 reply 0 retweets 9 likes
      Show this thread
    9. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      But there are two more points: Firstly, #polyphenols is a class of compounds with a huge number of members (https://www.springer.com/gp/book/9780412224805 …) - it is unlikely that they all have the same effect on health. Secondly: if they have an effect on health - why should it be only beneficial?

      1 reply 1 retweet 5 likes
      Show this thread
    10. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019

      The adverse effects of green tea extract (liver damage) is well known, as are the dangers of #curcumin. But there are #polyphenols where habitual intake is cause for concern.

      2 replies 0 retweets 6 likes
      Show this thread
      Health Nerd‏Verified account @GidMK 17 Dec 2019
      Replying to @ggkuhnle

      I haven't read much on the dangers of curcumin. Any good links?

      12:15 PM - 17 Dec 2019
      • 1 Like
      • Captain Science PhD
      1 reply 0 retweets 1 like
        1. New conversation
        2. Gunter Kuhnle‏ @ggkuhnle 17 Dec 2019
          Replying to @GidMK

          There are a few case reports - e.g. here:https://www.hindawi.com/journals/crihep/2019/6741213/ …

          1 reply 0 retweets 1 like
        3. This Tweet is unavailable.
        4. Show replies

      Loading seems to be taking a while.

      Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

        Promoted Tweet

        false

        • © 2021 Twitter
        • About
        • Help Center
        • Terms
        • Privacy policy
        • Cookies
        • Ads info