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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 29 Oct 2019

      HAHAHA I LOVE THIS STUDY: - n=45 - most of the comparisons were within-group - they ate A WHOLE AVOCADO A DAY - no improvement in most markers of heart disease - FUNDED BY BIG AVOCADO (seriously)pic.twitter.com/0Dg9dNW9TF

      9 replies 30 retweets 152 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK 29 Oct 2019

      Study is here:https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxz231/5588100#164455691 …

      1 reply 1 retweet 1 like
      Show this thread
    3. Health Nerd‏Verified account @GidMK 29 Oct 2019

      Basically, the scientists carefully designed three diets: - low-fat - medium-fat - AVOCADOpic.twitter.com/y7tse15NNl

      1 reply 3 retweets 16 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK 29 Oct 2019

      The diets were pretty much identical in many ways, except for the fat content and the inclusion of the smooshed avopic.twitter.com/jSFE1kCdyN

      1 reply 0 retweets 6 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK 29 Oct 2019

      The results were hilariously unimpressive Avocados reduced LDL ('bad') cholesterol a tiny bit, and changed the levels of a couple of antioxidants a tiny bit as wellpic.twitter.com/rF2czhzJgg

      1 reply 1 retweet 6 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK 29 Oct 2019

      (For reference, the reduction in LDL here is <10% from baseline, while guidelines tend to argue for a 50% reduction if possible)

      1 reply 0 retweets 9 likes
      Show this thread
      Health Nerd‏Verified account @GidMK 29 Oct 2019

      So, there was a minimally important reduction in 'bad' cholesterol But here's the funny part - it may not be important at all!

      5:31 PM - 29 Oct 2019
      • 5 Likes
      • 🧸⃤ ethoonnu Chellefire and Brimstone transplantrockstar Christina
      1 reply 0 retweets 5 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK 29 Oct 2019

          This is because, like many of these silly food studies, the researchers did a lot of what's known as "within-group" comparisons

          1 reply 0 retweets 10 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK 29 Oct 2019

          Basically, this means that you compare the avocado diet at the end to the avocado diet at the beginning, rather than the control groups that they had This makes the result a bit meaningless because of regression to the mean (among other things)pic.twitter.com/TgLwBWRfeD

          1 reply 0 retweets 11 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK 29 Oct 2019

          If you ignore all the within-group comparisons, you're left with this. Avocados: - increase lutein concentrations a tiny bit - increase carotene concentrations (but less than another medium-fat diet) - decrease 'bad' cholesterol by ~4% more than another medium-fat dietpic.twitter.com/RQ3PZGXCrq

          1 reply 0 retweets 4 likes
          Show this thread
        5. Health Nerd‏Verified account @GidMK 29 Oct 2019

          And remember, these weren't (as the headlines suggest) people just adding avocados to their diets! These were people eating care-fully controlled, formulated diets centered around avocados

          1 reply 0 retweets 7 likes
          Show this thread
        6. Health Nerd‏Verified account @GidMK 29 Oct 2019

          It is ABSURD to suggest that you could take these complex, within-study diets and apply the results to people who are wondering what to eat to be a bit healthier

          1 reply 1 retweet 13 likes
          Show this thread
        7. Health Nerd‏Verified account @GidMK 29 Oct 2019

          So why were the results blown so wildly out of proportion by the media (seriously, this was a pretty meaningless study)? Hard to say. But, could be to do with the funders of the trial...

          1 reply 0 retweets 3 likes
          Show this thread
        8. Health Nerd‏Verified account @GidMK 29 Oct 2019

          Yes, this research was funded by the Hass Avocado Board, the organisation for the most commonly-grown avocado in the world (who the senior study author also works for) In other words, BIG AVOCADOpic.twitter.com/AgfBmsVIxY

          1 reply 2 retweets 13 likes
          Show this thread
        9. Health Nerd‏Verified account @GidMK 29 Oct 2019

          (As a side note, I'm confused how you can be employed by an organisation and then claim that they had no role in your study design - sure, not your primary role, but still...)

          1 reply 0 retweets 9 likes
          Show this thread
        10. Health Nerd‏Verified account @GidMK 29 Oct 2019

          Another ~truly amazing~ thing about this study? The trial registration specifies 4 primary outcomes (total cholesterol, HDL, trigs, AND LDL) They only reported one I WONDER WHY THAT MIGHT BE????pic.twitter.com/TwaDjM733C

          2 replies 1 retweet 15 likes
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        11. Health Nerd‏Verified account @GidMK 29 Oct 2019

          There is some mention of HDL cholesterol, but only in reference to CETP (enzyme changes), nothing on differences between diets and nothing at all on triglycerides or total cholesterol!!!pic.twitter.com/J85nBIjNaJ

          1 reply 0 retweets 4 likes
          Show this thread
        12. Health Nerd‏Verified account @GidMK 29 Oct 2019

          In summary: - industry-funded study - showed pretty much no benefit for avocados - didn't report 3 out of 4 primary outcomes (!) - probably doesn't apply to most people anyway

          2 replies 0 retweets 16 likes
          Show this thread
        13. End of conversation

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