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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Ricky Turgeon PharmD‏ @Ricky_Turgeon 23 Oct 2019

      Ricky Turgeon PharmD Retweeted European Society of Cardiology Journals

      @hswapnil @thebyrdlab 🤔 is this was reignited the chromotherapy discuss yesterday? It seems like a deliberate effort is being made to obfuscate whether this is actually an RCThttps://twitter.com/ESC_Journals/status/1186934294347964416 …

      Ricky Turgeon PharmD added,

      European Society of Cardiology JournalsVerified account @ESC_Journals
      Routine ingestion by hypertensive patients of BP-lowering medications at bedtime, as opposed to upon waking, resulted in improved BP control and markedly diminished occurrence of major CV events http://bit.ly/2pJceDT  @escardio #EHJ @TomLuscher #cardiotwitter pic.twitter.com/lTJK3Z0yo5
      4 replies 8 retweets 15 likes
      Show this thread
    2. Swapnil Hiremath‏ @hswapnil 23 Oct 2019
      Replying to @Ricky_Turgeon @thebyrdlab

      They do say randomized, but I didn’t find method of randomization anywhere in text 🤔 The table 1 is impressive toopic.twitter.com/sj4kl27p6S

      2 replies 0 retweets 5 likes
    3. Ricky Turgeon PharmD‏ @Ricky_Turgeon 23 Oct 2019
      Replying to @hswapnil @thebyrdlab

      There are a few things from this trial that I still don't quite understand. (1) If the results are to be believed, how was this trial not stopped much earlier? Was there no safety monitoring committee? The HRs are astounding & the 95%CIs incredibly narrow. 1/

      2 replies 2 retweets 8 likes
    4. Ricky Turgeon PharmD‏ @Ricky_Turgeon 23 Oct 2019
      Replying to @Ricky_Turgeon @hswapnil @thebyrdlab

      2/ (2) Where are the unadjusted HRs & per-group event rates? I can only eyeball some of the endpoint rates from the Kaplan Meier curves, but shouldn't need to. How many people in each group died? How many people in each group had a "hard" CV endpoint?

      1 reply 1 retweet 3 likes
    5. Ricky Turgeon PharmD‏ @Ricky_Turgeon 23 Oct 2019
      Replying to @Ricky_Turgeon @hswapnil @thebyrdlab

      3/ (3) On the note of adjusting HRs, I'm unclear on the appropriateness of the methods here: variables weren't selected a priori but by stepwise selection. This concern would easily be assuaged if unadjusted HRs were also presented. (I wonder if @ADAlthousePhD has thoughts?)pic.twitter.com/9Qp48mTOEv

      1 reply 0 retweets 2 likes
    6. Andrew Althouse‏ @ADAlthousePhD 23 Oct 2019
      Replying to @Ricky_Turgeon @hswapnil @thebyrdlab

      Briefly discussed this elsewhere, will try to concentrate my thoughts here now that I realize that this is the same trial being discussed on that other thread @S_brimble and @hswapnil tagged me into...

      1 reply 0 retweets 3 likes
    7. Andrew Althouse‏ @ADAlthousePhD 23 Oct 2019
      Replying to @ADAlthousePhD @Ricky_Turgeon and

      1) On whether this was a "randomized" trial. The word randomized is used once, and there is an NCT number (https://clinicaltrials.gov/ct2/show/NCT00741585 …) which says it was randomized, but the paper is light on details, though this could just be poor reporting...

      2 replies 0 retweets 5 likes
      Health Nerd‏Verified account @GidMK 23 Oct 2019
      Replying to @ADAlthousePhD @Ricky_Turgeon and

      They do also reference the "assigned" treatment a few times, which implies at least an interventional study

      5:08 PM - 23 Oct 2019
      0 replies 0 retweets 0 likes

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