And the conclusions This is how bogus supplements are born!pic.twitter.com/AXUjiXxPoy
Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him
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And the conclusions This is how bogus supplements are born!pic.twitter.com/AXUjiXxPoy
Ping @ADAlthousePhD @jamesheathers gotta love the sperm paper
I'll have to avoid puns here and be an adult, or this will quickly descend into ... no, I'm not doing it. So, here's the clinical trial reg. Primary outcome: Motile sperm concentration http://www.isrctn.com/ISRCTN33248724
Week 6 is in the registration, and mentioned in the paper, but the data is not reported. What happened to the midpoint variables?
Primary endpoint demoted to halfway through the primary results. And as you have noted, it looks like they can't even be bothered with comparing the treatment effect to the placebo effect. This is ridiculous, as it looks like their 'p=0.058' would get washed by it.pic.twitter.com/AzXcAWVym2
This data has more right tail than a left-facing lemur, so how do people normally assess this? It can't be with two boggo within-subjects tests that don't meet in the middle.
Interesting point: crappy no-multiple-comparisons tests also *prevent* what looks like a decrease in selenium in the placebo group, and an increase in the MAGIC TERMATOES group. Selenium is quite important for spermses.
"Sperm capsule selenoprotein is localised in the mid-peice portion of spermatozoa where it stabilises the integrity of the sperm flagella." So, you know, good covariate. And the pairwise tests potentially geek it. LOOK.pic.twitter.com/nR8f65KTqa
We can make synthetic data with SPRITE and test this approximately. So, how do you analyse a 2*2 between-within dataset with savagely right-tailed data?
Can't think of a right way. Also, those are medians and IQRs. Ugh. I'd have to code that from scratch. DO NOT WANT.
Don't think it's necessary tbh. Enough there without any numerical errors 
How dare you interfere with my opportunities for learning.
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