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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 10 Sep 2019

      This is another pretty simple epidemiological study - take a large cohort of people, split them up by how much they nap, and see who's at a higher risk of heart diseasepic.twitter.com/9UzG6BDrG7

      1 reply 1 retweet 1 like
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    2. Health Nerd‏Verified account @GidMK 10 Sep 2019

      Basically, the researchers found that people who napped 1-2 times a week had the lowest risk of cardiovascular events (heart disease), while those who napped 6+ times a week had the highestpic.twitter.com/B39pabnkZn

      1 reply 1 retweet 1 like
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    3. Health Nerd‏Verified account @GidMK 10 Sep 2019

      However, after correcting for some fairly simple confounding variables, the relationship disappeared for the 6+ nappers, although the reduced risk for 1-2 per week nappers remained significantpic.twitter.com/oLYCbQzN8w

      1 reply 2 retweets 4 likes
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    4. Health Nerd‏Verified account @GidMK 10 Sep 2019

      However, something that wasn't reported on in the media is that the protective effect of 1-2 naps a week ENTIRELY DISAPPEARED when you controlled for Obstructive Sleep Apnea (OSA)pic.twitter.com/UFxsDf4Z9H

      2 replies 4 retweets 5 likes
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    5. Health Nerd‏Verified account @GidMK 10 Sep 2019

      In other words NAPS DIDN'T HAVE MUCH OF AN EFFECT AT ALL ONCE YOU CONTROLLED FOR OSA This was, surprisingly, relegated to a single sentence in the results and a somewhat incomplete explanation in the limitations section of the paperpic.twitter.com/WjbU5nFOdV

      1 reply 2 retweets 3 likes
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    6. Health Nerd‏Verified account @GidMK 10 Sep 2019

      It's plausible that the relationship was attenuated because of the reduced sample size It's also plausible that it was attenuated because OSA causes people to nap and it's an example of classic confounding/reverse causality

      2 replies 1 retweet 5 likes
      Show this thread
    7. David Colquhoun  💙‏ @david_colquhoun 10 Sep 2019
      Replying to @GidMK

      But small sample sizes tend to exaggerate effect sizes, not attenuate them

      1 reply 0 retweets 1 like
    8. Health Nerd‏Verified account @GidMK 10 Sep 2019
      Replying to @david_colquhoun

      Oh the point estimate was still similar but the confidence interval grew quite a bit. The issue I have is that OSA is known to cause both napping and cardiovascular disease, so I cannot see how any analysis that doesn't adjust for it makes sense

      1 reply 0 retweets 0 likes
    9. David Colquhoun  💙‏ @david_colquhoun 10 Sep 2019
      Replying to @GidMK

      sadly, very little observational epidemiology makes sense. Just look at nutrition studies -total chaos. And the worst thing about that is that it makes people laugh at science.

      1 reply 0 retweets 0 likes
    10. Health Nerd‏Verified account @GidMK 10 Sep 2019
      Replying to @david_colquhoun

      I'd disagree. Lots of observational epidemiology makes sense, in my opinion the disconnect is in the communication of those findings and their interpretation

      2 replies 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 10 Sep 2019
      Replying to @GidMK @david_colquhoun

      For example, we recently published a paper identifying a surprising increase in diabetes rates and are about to submit another on the risks of GPs not diagnosing T2DM in practice. Both entirely observational, but I'd say the findings are pretty robust

      4:17 PM - 10 Sep 2019
      0 replies 0 retweets 0 likes

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