We can't have health at every size but we can experience dignity at every size. We can appreciate and care for others at every size. We need to understand the risks imposed by excess adiposity & deliver effective compassionate treatment. We need to heal weight bias & stigma.
From my understanding it was a combination of the two. I've heard some calls to abolish pre-diabetes completely and just make 6 diagnostic for diabetes
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I can see the rational for that (but could also understand the pushback that would occur). If I were a co. making GLP1a I'd focus on the pre-DM pts. By the time T2D has occurred we've already lost 50% of beta-cell function -- things have already gotten out of hand by that point.
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The challenge is that intervening for established T2DM has a much better short term ROI than prevention!
End of conversation
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. The rest is speculation.
Weight-height tables were used by insurance companies to predict mortality. This is an associative, not causal relationship.
BMI has a long & twisted history, with an origin in stats, not biology. See Hite & Carter 2019.
risk of macrovascular events but not aware of a clear "inflection" point.