I have attributed the folic acid/birth defect link as a win for nutritional epi, but here @martijnkatan says it isn't.https://twitter.com/martijnkatan/status/1153957567535751168 …
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Yes. The caveat is always that it was very useful for finding deficiency diseases. The question is how useful epi is beyond that.
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What about the role of fibre?
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Fluoride and tooth decay did not come out of epidemiological cohorts. Kids in high fluoride towns just had no cavities. A better example is diet and kidney stones. Harvard found that dietary calcium protects against calcium stones, and trials confirmed it. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599330/ …
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I'm not sure there's anything more quintessentially epidemiological than case control studies looking at dental caries in villages with and without high levels of fluoride
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