The risk increase is for a combined cardiovascular endpoint. Basically, heart attacks, strokes, and death That's a pretty serious combinationpic.twitter.com/5q2Zuypo4b
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The study looked at men who were being prescribed testosterone for age-related decline in the UK. Even though it's an emerging treatment, they found >15,000 people who'd taken these drugs
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They found that the rate of their combined endpoint went from 1.1% to 1.3% each year when you took the drugs
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Now, think about that for a second. This is a group of drugs that are ~already~ being prescribed to 10,000s of men in the UK
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Imagine that 100,000 men are prescribe the drugs and take them for an average of 5 years over the next decade
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That makes 500,000 person-years of drug-taking Now, we know that for every 1,000 person-years there are about 2 events (0.2%)
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That means that this drug will cause 500*2 = 1,000 heart attacks/strokes/deaths in the next 5 years That's pretty hugepic.twitter.com/LgvnqKstKp
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If a million people take the drugs for 5 years, they'll cause 10,000 events And on, and on
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The thing is, a risk doesn't need to be huge (21% increase!) to be massively impactful at the population scale End rant
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End of conversation
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Out of interest, do you have any insight on testosterone replacement for older gentleman? Specifically, what the major ramifications are vs. the benefits? Anecdotally at least, I’ve heard it really having a positive effect on ~40+ men, mainly if they’re athletic individuals.
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