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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Kevin Bass, MS‏ @kevinnbass 17 Jul 2019
      Replying to @LDLSkeptic @AmirWeiss1 and

      This is not true. Stroke is at p=0.05 and ischemic at p<0.008. All other outcomes were individually significant except fatal MI. Nonfatal MI was 0.002. And that's with an incredibly modest change in LDL!!!pic.twitter.com/ZYEKGOvf90

      5 replies 0 retweets 2 likes
    2. Amir Weiss‏ @AmirWeiss1 17 Jul 2019
      Replying to @kevinnbass @LDLSkeptic and

      In each group about 530 people died of a cardiovascular even but over 700 people died of other causes. What killed them? Is this mentioned in the paper? This is very odd. HD is #1 cause of death, but not in this group of patients with prior MI? Or maybe I'm the problem?

      1 reply 0 retweets 4 likes
    3. David Diamond‏ @LDLSkeptic 17 Jul 2019
      Replying to @AmirWeiss1 @kevinnbass and

      This is a common problem in CHD studies. All cause mortality is almost never affected - maybe never. The change in CHD mortality is typically small and lost in the noise of total death.

      1 reply 0 retweets 11 likes
    4. Kevin Bass, MS‏ @kevinnbass 17 Jul 2019
      Replying to @LDLSkeptic @AmirWeiss1 and

      These studies are not powered to detect changes in ACM and maybe not CVM and are of a short duration. Meta-analyses show clear reduction in ACM and CVM. In 2019, MI creates much more disability in the short-term than death. That's what the drugs are preventing in these studies.

      5 replies 0 retweets 1 like
    5. David Diamond‏ @LDLSkeptic 17 Jul 2019
      Replying to @kevinnbass @AmirWeiss1 and

      We're just going to have to agree to disagree as to the value of these findings. I'm not excited about a small benefit under very controlled conditions with potentially substantial adverse effects, which even Nissen et al say could occur in up to 40% of patientspic.twitter.com/fsGwHrD2KJ

      3 replies 0 retweets 6 likes
    6. Kevin Bass, MS‏ @kevinnbass 17 Jul 2019
      Replying to @LDLSkeptic @AmirWeiss1 and

      Nearly 30% reduction in heart attack incidence (FOURIER) is not a "small benefit" given the cost to QOL of permanent disability from MI, and a 40% substantial adverse side effects figure is one person's opinion. What is the evidence?

      3 replies 1 retweet 1 like
    7. Kevin Bass, MS‏ @kevinnbass 17 Jul 2019
      Replying to @kevinnbass @LDLSkeptic and

      Placebo-controlled RCT shows side effects rarely above placebo (nocebo) for statins. I don't know PCSK9 well. If you don't want to argue anymore, up to you certainly.

      2 replies 0 retweets 0 likes
    8. David Diamond‏ @LDLSkeptic 17 Jul 2019
      Replying to @kevinnbass @AmirWeiss1 and

      The nocebo work is flawed, and addressed only muscle issues, but I won't bother with that now. There are many other side effects measured physiologically, not subject to nocebo, such as the statin time/dose ⬆️ in new onset T2D.pic.twitter.com/Hoh1jiNg2M

      3 replies 0 retweets 3 likes
    9. Kevin Bass, MS‏ @kevinnbass 17 Jul 2019
      Replying to @LDLSkeptic @AmirWeiss1 and

      Insulin resistance side effect is important and risk of T2DM complications needs to be weighed against benefits (as with all medications). That said, one of the most important complications of T2DM is CVD and statins treat CVD. Medications are a balancing act.

      2 replies 0 retweets 1 like
    10. David Diamond‏ @LDLSkeptic 17 Jul 2019
      Replying to @kevinnbass @AmirWeiss1 and

      It's not just T2D. Statin side effects are more extensively documented than most are aware. We included 60 peer-reviewed papers documenting statistically sig findings of statin side effects in >dozen categories https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205138 … - see below @IMWHorvitzpic.twitter.com/10KX3l3epV

      5 replies 2 retweets 16 likes
      Health Nerd‏Verified account @GidMK 17 Jul 2019
      Replying to @LDLSkeptic @kevinnbass and

      Having a look through those references - I'm not sure the phrase "statistically significant" applies actually. For example, the reference for "severe irritability" links to this 2004 case series of 6 patientspic.twitter.com/bhAWL2lB1W

      5:21 PM - 17 Jul 2019
      • 1 Like
      • Kevin Bass, MS
      2 replies 0 retweets 1 like
        1. New conversation
        2. Health Nerd‏Verified account @GidMK 17 Jul 2019
          Replying to @GidMK @LDLSkeptic and

          The references for "fatigue" (38,39) are a perspective piece and a conference abstract that was never written up as a paper as far as I can tell. The conference abstract, funnily enough, didn't show a "statistically significant" reduction from statinspic.twitter.com/FX4WM2OoSp

          2 replies 0 retweets 1 like
        3. Health Nerd‏Verified account @GidMK 17 Jul 2019
          Replying to @GidMK @LDLSkeptic and

          The reference for "exertional fatigue" is another publication from the same study as the previous conference abstract, which found a statistically (although arguable clinically) significant drop in energy of ~2% associated with statin usepic.twitter.com/RxBPUacHRn

          1 reply 0 retweets 1 like
        4. Show replies
        1. New conversation
        2. David Diamond‏ @LDLSkeptic 17 Jul 2019
          Replying to @GidMK @kevinnbass and

          The finding of a reversible change in personality shouldn't be minimized. This is the kind of finding that docs should be aware of. Low cholesterol has been associated with increased aggression.pic.twitter.com/UOL8g09qNv

          1 reply 0 retweets 0 likes
        3. Health Nerd‏Verified account @GidMK 17 Jul 2019
          Replying to @LDLSkeptic @kevinnbass and

          I'd argue that it's pretty hard to make any definitive statements from a case series of 6 patients, and it certainly doesn't support the statement of "statistically significant" results as no statistical comparisons were made

          0 replies 0 retweets 0 likes
        4. End of conversation

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