I feel like it would be hard to see up a breastfeeding intervention ethically?
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Replying to @synapse101
Maybe not breastfeeding per se, but you could test the success of an intervention aimed at getting more women to breastfeed
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Replying to @GidMK
But that's not really the same question. This is a big difficulty in getting people to understand nutrition research a RCT is not always possible/practical or ethical and indeed is not always the top of the hierarchy of evidence.
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Replying to @synapse101
Absolutely true. I just find it hard to believe that there are a vast plethora of interventions aimed at increasing breastfeeding but I can't find any research on whether they improve health outcomes associated with non-breastfeeding
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Replying to @GidMK @synapse101
Check out the PROBIT RCT - BF support, with range of outcomes up to child age 16y reported to date https://clinicaltrials.gov/ct2/show/NCT01561612 … cc
@MullanBarbara@Becky_K_White2 replies 0 retweets 3 likes -
Replying to @MaritaHennessy @synapse101 and
A lot of fascinating research there, I'm going to have to do some reading! Although, from some of the first few publications reporting long-term results...pic.twitter.com/fLTQHVUntO
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Replying to @GidMK @MaritaHennessy and
Right, so afaik PROBIT is the only RCT conducted in high-income country to look at effects bf promotion on health outcomes (infant/mother). Many, many other RCT of bf support (I was involved in a SR of this), showing impact on bf rates but generally not assessing health outcomes
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Replying to @veitchemma @GidMK and
PROBIT achieved substantial improvements in bf duration (all babies in the trial were breastfed) and "as randomized" analysis shows subsequent impact on diarrhoea episodes and rashes, some possible improvements on (some) neurocognitive outcomes
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Replying to @veitchemma @GidMK and
But many of the benefits claimed in observational studies and providing the foundation for health policy in this area, don't replicate in PROBIT or in other causal inference efforts (eg, sibling controls, cross-cohort comparisons with different confounding structures)
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Replying to @veitchemma @GidMK and
Sorry if that's a bit boring, I can link papers later - let me know if you are interested. I used to do voluntary support in this sector but have to say I'm a bit of an (open) skeptic around the science now!
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Not boring at all! As I said, this is about as far from my area of expertise as is possible. Would love the links to the other studies 
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Replying to @GidMK @MaritaHennessy and
Okey-dokey... this might need a few tweets. To avoid offences against the Twittiquette Act, think I'll do as a separate thread and then subtweet in here...
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