Someone explain to me why so many centenarians from NHANES have FH? They should have died 70 years ago without a statinpic.twitter.com/n0ZmjSDTL8
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You could do this with a retrospective cohort design rather than the case-control you're thinking of. This tells you how many people have the triad and die vs the number that survive to 100
Would love to. If you've followed me for a while, I know just how much I'd love to get ahold of more raw datasets to test this out directly. Obviously, Framingham Offspring would be especially useful given followups, etc.
Technically, the sample size is 124 of those 84/85 in the NHANES dataset. The five are the ones who have categorically survived to 100 and are still alive at last check.
Mmmm but for this kind of study 124 is still far too few. You'd want at least that many cases, and then link to 2-3x as many matched controls. Even then, it's going to be biased, but at least you'd be able to make some statistical comparisons
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