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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Dr. Tro‏ @DoctorTro 24 May 2019

      Someone explain to me why so many centenarians from NHANES have FH? They should have died 70 years ago without a statinpic.twitter.com/n0ZmjSDTL8

      Dave Feldman, Prof Darrel Francis  ☺ Mk CardioFellows Great Again, Ethan Weiss and 7 others
      1. Dave Feldman @DaveKeto

      2. Prof Darrel Francis  ☺ Mk CardioFellows Great Again @ProfDFrancis

      3. Ethan Weiss @ethanjweiss

      4. Sek Kathiresan MD @skathire

      5. DrKKWate @ChristianAssad

      6. Ken D Berry MD @KenDBerryMD

      7. Bret Scher, MD @bschermd

      8. Shariq Shamim @ShariqShamimMD

      9. Ryan P. Daly, MD @DrRyanPDaly

      10. Eric Sodicoff  👨🏻‍⚕️ @ESodicoffMD

      15 replies 30 retweets 143 likes
    2. Ethan Weiss‏ @ethanjweiss 24 May 2019
      Replying to @DoctorTro @DaveKeto and

      Tro!

      2 replies 0 retweets 6 likes
    3. Dave Feldman‏ @DaveKeto 24 May 2019
      Replying to @ethanjweiss @DoctorTro and

      I'm curious what you'd say, @ethanjweiss. The "reverse causality" hypothesis doesn't really work in this case, as these are all very elevated LDL-C levels 16 years prior... and likely not a coincidence they match up with high HDL and low TG, no?

      2 replies 0 retweets 3 likes
    4. Health Nerd‏Verified account @GidMK 27 May 2019
      Replying to @DaveKeto @ethanjweiss and

      The obvious answer would be survivorship bias of some description. People who survive to 100 are weird in many ways!

      1 reply 0 retweets 3 likes
    5. Dave Feldman‏ @DaveKeto 27 May 2019
      Replying to @GidMK @ethanjweiss and

      ... and yet, they are surprising near uniform in the triad thus far. I’m excited to see upcoming centenarians and how much/little we see this phenomenon continue.

      1 reply 0 retweets 0 likes
    6. Health Nerd‏Verified account @GidMK 27 May 2019
      Replying to @DaveKeto @ethanjweiss and

      Why?

      1 reply 0 retweets 1 like
    7. Dave Feldman‏ @DaveKeto 27 May 2019
      Replying to @GidMK @ethanjweiss and

      I want to see how common the triad is in centenarians (High LDL, high HDL, low TG) when tested a decade and a half earlier.

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 27 May 2019
      Replying to @DaveKeto @ethanjweiss and

      But you'd still be seeing survivorship bias there. You're seeing the people who, for whatever reason, can be in that state and live for a long time. Doesn't say much about the rest of the population imo

      1:59 PM - 27 May 2019
      1 reply 0 retweets 0 likes
        1. New conversation
        2. Dave Feldman‏ @DaveKeto 27 May 2019
          Replying to @GidMK @ethanjweiss and

          Survivorship bias makes sense if we were testing these 100/101 year olds a year earlier. But I'm emphasizing these markers (high LDL, high HDL, low TG) were taken 15 years earlier when they were age 84/85. The other 118 of those 84/85 taken at that time are not centenarians.

          1 reply 0 retweets 1 like
        3. Health Nerd‏Verified account @GidMK 27 May 2019
          Replying to @DaveKeto @ethanjweiss and

          Well, the sample size is still tiny. But even so, the case-control you're suggesting would definitely be open to survivorship bias, because you're selecting people who have lived a very long time. More appropriate to start at, say 50, and see how many make it to 100

          2 replies 0 retweets 2 likes
        4. Show replies

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