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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Nicola Guess‏ @Dr__Guess 20 May 2019

      Nicola Guess Retweeted Nina Teicholz

      I 😍 what Virta are doing & their results are in line with other studies. However, interesting to see intellectual somersaults performed to justify why the Virta COIs are not really COIs. "Results are still results" (same true of any pharma trial?)https://twitter.com/bigfatsurprise/status/1130491276544151553 …

      Nicola Guess added,

      Nina Teicholz @bigfatsurprise
      Replying to @Hall_science @AmDiabetesAssn and 2 others
      Fair issue to raise and is raised w/ big pharma. However, results are still results. You cannot pay someone to reverse their diagnosis of T2 diabetes nor fake their weight loss/blood pressure etc. Study run through a university with University oversight.
      20 replies 8 retweets 45 likes
    2. Health Nerd‏Verified account @GidMK 20 May 2019
      Replying to @Dr__Guess

      It's also a bit frustrating to see all of the major research flaws in the Virta trial design dismissed as totally fine by people who will pick apart any study that suggests that there is another way than low carb

      2 replies 0 retweets 14 likes
    3. Health Nerd‏Verified account @GidMK 20 May 2019
      Replying to @GidMK @Dr__Guess

      I mean, they're getting great results, but those are within-group comparisons of a non-randomized trial. If this was pharma we'd all be rightly skeptical and probably dismiss the results completely

      2 replies 0 retweets 9 likes
    4. Nicola Guess‏ @Dr__Guess 20 May 2019
      Replying to @GidMK

      disagree! I think any lifestyle intervention which can get 50% of people off insulin (and half units in other 50%) is pretty exciting clinically. I think they've really shown what can be possible for people.

      1 reply 0 retweets 3 likes
    5. Health Nerd‏Verified account @GidMK 20 May 2019
      Replying to @Dr__Guess

      But the problem for me is how much of that is the program and how much may have been influenced by the study design. It's very challenging for me to interpret these results because there's no way to tell how much of a role regression to the mean might have played

      1 reply 0 retweets 0 likes
    6. Nicola Guess‏ @Dr__Guess 20 May 2019
      Replying to @GidMK

      but I cannot think of a scenario in which people with type 2 diabetes of an average of 8 years duration come of their insulin as part of natural variation?

      1 reply 0 retweets 0 likes
    7. Health Nerd‏Verified account @GidMK 20 May 2019
      Replying to @Dr__Guess

      One thing suggested by a friend of mine was the use of newer meds (SGLT2, GLP1, DPP4s). There's also decent evidence that simply being enrolled in a study can help with things like weightloss, as well as the underlying statistical variation

      1 reply 0 retweets 2 likes
      Health Nerd‏Verified account @GidMK 20 May 2019
      Replying to @GidMK @Dr__Guess

      Also worth noting that you can't tell from this abstract who this analysis was done on - it's possible that this is ITT, but given the previous studies I think it's possible that this is "as-treated" which may be inflating the results

      4:41 PM - 20 May 2019
      1 reply 0 retweets 0 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK 20 May 2019
          Replying to @GidMK @Dr__Guess

          So it looks like they've published a pre-print and the results are interesting. The between-group differences are significant, although some of them do appear to be attenuated (in particular diabetes reversal/remission)https://www.biorxiv.org/content/10.1101/476275v3.full#T6 …

          1 reply 0 retweets 0 likes
        3. Health Nerd‏Verified account @GidMK 20 May 2019
          Replying to @GidMK @Dr__Guess

          That being said, I'm super confused why they used the within-group variation in their abstract, many of the between-group values were similar (although slightly lower) and the within-group comparisons are not nearly as valuable

          0 replies 0 retweets 0 likes
        4. End of conversation

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