If a systematic review finds only small, poorly-done studies on a topic but they have mostly null results should it conclude #EpiTwitter
That's definitely true, but I'm thinking of the opposite - if we have a bunch of small studies indicating no effect, taking into account publication bias, is there a rationale for conducting more research?
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Hmmm I think that’s tricky and could be argued either way. But I’d say if you can get the support of a couple of large high powered studies I would feel more comfortable with the answer (clinically speaking angle here)
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