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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 11 Apr 2019
      Replying to @MEMilitant1 @Students4BE

      Apologies, I'm getting confused with the new tool. The answer would be that they used patient-reported outcomes, but whether that indicates a high risk of bias is a judgement call, and I'd say no in this case due to the things I've mentioned

      1 reply 0 retweets 0 likes
    2. MEmilitant‏ @MEMilitant1 11 Apr 2019
      Replying to @GidMK @Students4BE

      "Is it likely that assessment of the outcome was influenced by knowledge of intervention received?" with patient-reported symptoms in trials of homeopathy given as example of 'yes', & you'd answer 'no' for this CBT trial relying on subjective self-report? I don't understand why.

      2 replies 0 retweets 0 likes
    3. Health Nerd‏Verified account @GidMK 11 Apr 2019
      Replying to @MEMilitant1 @Students4BE

      No it is certainly likely that the assessment was influenced. Whether this biases the study, however, is another question, and that's the point. They implemented a number of controls to reduce this bias, so I'd argue that it's not a high risk

      1 reply 0 retweets 0 likes
    4. MEmilitant‏ @MEMilitant1 11 Apr 2019
      Replying to @GidMK @Students4BE

      But if you agree assessment was likely influenced then following RoB2 you necessarily get a high risk of bias in that domain. I'm not so impressed by their other controls to reduce bias, but subjective judgements on that are outside of this assessment tool anyway.pic.twitter.com/N71k4eBTat

      1 reply 0 retweets 0 likes
    5. Health Nerd‏Verified account @GidMK 11 Apr 2019
      Replying to @MEMilitant1 @Students4BE

      Mmm that's the default, but as I said RoB assessment isn't a hard rule. Look at the sentence underneath the title of that graphicpic.twitter.com/ZhtiXjh7bq

      1 reply 0 retweets 1 like
    6. MEmilitant‏ @MEMilitant1 11 Apr 2019
      Replying to @GidMK @Students4BE

      That line wasn't in the copy I was looking at: https://drive.google.com/file/d/1jjOMDIZMtDcXS9QFD-n8DIRlp06CRLEc/view … My 'necessarily' may have been too strong, but I don't see any clear reason for over-riding the default for this trial. It fulfils that RoB2 criteria for 'high risk', and with good reason imo.

      1 reply 0 retweets 0 likes
    7. Health Nerd‏Verified account @GidMK 11 Apr 2019
      Replying to @MEMilitant1 @Students4BE

      Oh odd. I just went to the Cochrane site and navigated to the RoB tool. I've said why I don't think it's high risk so I guess we'll just have to agree to disagree 👍

      1 reply 0 retweets 0 likes
    8. Health Nerd‏Verified account @GidMK 11 Apr 2019
      Replying to @GidMK @MEMilitant1 @Students4BE

      That being said, we agree that it's likely not possible to run a trial at less risk of bias on this topic so why does it matter? This is probably the best you can get, doesn't mean CBT is 100% effective but it does provide some fairly strong evidence

      1 reply 0 retweets 0 likes
    9. MEmilitant‏ @MEMilitant1 11 Apr 2019
      Replying to @GidMK @Students4BE

      I don't agree! eg I linked to this old RCT of CBT for CFS that included a placebo & drug arm, helping to account for problems with bias: https://www.amjmed.com/article/0002-9343(93)90183-P/abstract … Also, if A vs A+B trials & subjective self-report outcomes provide fairly strong evidence for CBT, they do for CAM too.pic.twitter.com/DHXuYOlk4q

      1 reply 0 retweets 0 likes
    10. MEmilitant‏ @MEMilitant1 11 Apr 2019
      Replying to @MEMilitant1 @GidMK @Students4BE

      Rgardless of the merits of this trial design, researchers should make clear to readers, patients & journalists that reported improvements may merely reflect problems with bias. We can't be certain how much this is a problem but people should be informed of risk.

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 11 Apr 2019
      Replying to @MEMilitant1 @Students4BE

      Well I can't disagree with that. But frankly, I don't think communicating these complex issues is going to happen any time soon in most media

      5:12 PM - 11 Apr 2019
      0 replies 0 retweets 0 likes

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