Yes! And this argument is used to dismiss a lack of evidence for some alternative therapies: We can't measure the mechanism, so clinical efficacy trials are impossible (which isn't true). Clinically meaningful endpoints are so much more important, regardless of mechanism.
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Sounding like an engineer.
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idk that’s a hot take; Bradford Hill stirring a bit in his grave...
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Not for complex and behavioural interventions tho...?
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