What would happen if we then added another 100 GP clinics, or 500,000 patients, to the sample? Would it be more or less generalizable?
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This was actually central to the hypothesis of the Chinese study. The researchers argued that Chinese eating habits were different, and so the egg consumption should be studied to see if it was beneficial despite previous studies in other populations showing harmpic.twitter.com/Weto2IJUv1
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In fact, while the two studies APPEAR contradictory, it's likely that this is, in part, context-based Chinese people who eat more eggs are healthier Americans who eat more eggs are less healthy BOTH OF THESE THINGS CAN BE TRUEpic.twitter.com/x5x57XLrkG
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TL:DR - two studies appear contradictory (eggs good or bad?) Realistically, it's likely just the differences between the settings for the studies Bottom line, bigger studies are not always better it's more complicated than that
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P.s. the REASON that egg eating is associated with good or bad health is, in my opinion, more complex than either of these studies suggests
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My personal argument is that it's ~almost certain~ that both of these studies are using egg eating as a marker for some sort of social influence that is really causing the heart disease
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So people in the US who eat more eggs are probably less well off in many ways, with the inverse being true in China
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End of conversation
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Just OTOH hypothesis could be that in US eggs are often consumed with bacon and sausages, whilst in an Asian population egg consumption might often be alongside noodles and vegetables. Egg and CVD alone probably can't tell us much without controlling for rest of diet
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