The trouble with this ... https://twitter.com/KevinBlighe/status/1110537665089359873 …
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There's the counter from Ioannidis. So, just as an exercise, how would folk report the following data in the proposed New World? RCT, Rx vs control, outcome CV mortality, RR 0.71 [95% CI, 0.44 to 1.09] Obs study, exp vs non-exp, weight loss, -4.4kg [-9.3 to -0.3]
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Yeh, this is where I find it challenging as well. In that case, I guess the answer would be that there's a big decrease in CVD, probably linked to weight loss, but that there's a fair bit of uncertainty about the clinical significance of the effect on CVD
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To what? So even more unclear piece of statistical baffleglab? (mind the "trending towards" is pure nonsense
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Nah, just more uncertain answer. Not sure I entirely agree, but I don't think the argument is to make it more complex, just less binary
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