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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 24 Mar 2019

      Here's a question #epitwitter: If an n=80 study randomizes into two groups, stratified by age AND gender, is it still randomized?

      1 reply 1 retweet 0 likes
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    2. Health Nerd‏Verified account @GidMK 24 Mar 2019

      To me it seems to depend on how big the age bins are. If the stratification is by 5-year intervals, then you've got ~32 groups that you're randomizing participants into. That might make your study into a prospective cohort, 'randomized' by whoever is enrolled first

      1 reply 0 retweets 1 like
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    3. Health Nerd‏Verified account @GidMK 24 Mar 2019

      And if you're stratifying "by age" which is actually what the study in question reported, surely you'd basically just break your whole randomization? Is there something I'm missing here?

      1 reply 0 retweets 1 like
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    4. Allen Cheng‏ @peripatetical 24 Mar 2019
      Replying to @GidMK

      Stratification just ensures that there are the desired number of participants randomised in each age group, but they are randomly allocated within each group.

      2 replies 0 retweets 1 like
      Health Nerd‏Verified account @GidMK 24 Mar 2019
      Replying to @peripatetical

      Right but what happens if you have almost as many groups as participants?

      10:19 PM - 24 Mar 2019
      1 reply 0 retweets 0 likes
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        2. Allen Cheng‏ @peripatetical 24 Mar 2019
          Replying to @GidMK

          Then it just becomes a RCT. This sometimes happens in phase 2 cancer trials where there is stratification at a site level; they sometimes use complex algorithms (minimisation) to try to ensure balance while still randomly allocating treatments.

          1 reply 0 retweets 1 like
        3. Health Nerd‏Verified account @GidMK 24 Mar 2019
          Replying to @peripatetical

          Ah ok then. I see what you mean it isn't really an issue it just makes the stratification a bit pointless I guess

          1 reply 0 retweets 0 likes
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