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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Ali Torkamani‏ @ATorkamani 13 Mar 2019
      Replying to @cecilejanssens @statsepi @dahinds

      (Repost) Let me attempt to restate your stance then on this particular score. The T2D PRS is not useful if you are aware that you have high environmental risk. The T2D PRS is probably not useful for individuals that don't resemble the majority of the 23andMe userbase.

      1 reply 0 retweets 0 likes
    2. Ali Torkamani‏ @ATorkamani 13 Mar 2019
      Replying to @ATorkamani @cecilejanssens and

      Well - I guess we disagree on "unlikely useful for ***anyone***" If you are healthy, (near)European and you fall in the highest risk tier - 2X increase risk even with the relatively low incidence in healthy individuals is meaningful and worth investigating.

      2 replies 0 retweets 1 like
    3. Health Nerd‏Verified account @GidMK 13 Mar 2019
      Replying to @ATorkamani @cecilejanssens and

      So, presumably, the test should only ever be sold and marketed to people who meet those fairly exacting criteria, if at all?

      1 reply 0 retweets 0 likes
    4. Ali Torkamani‏ @ATorkamani 13 Mar 2019
      Replying to @GidMK @cecilejanssens and

      No - that is the group that the score is *most* useful for. It's a personal value judgement for the individual. Although yes - I would say on the marketing side it should be clear how well the test would perform across various groups - which is exactly what was done.

      1 reply 0 retweets 0 likes
    5. Health Nerd‏Verified account @GidMK 13 Mar 2019
      Replying to @ATorkamani @cecilejanssens and

      But what you're saying is that in the best case scenario the test - for people who are low on every other risk, resemble 23andMe userbase, and score in the highest risk tier - will inform people of a risk increase of, what, about 0.05%? Roughly?

      2 replies 0 retweets 0 likes
    6. Ali Torkamani‏ @ATorkamani 13 Mar 2019
      Replying to @GidMK @cecilejanssens and

      According to the white paper its >2X increase in lifetime risk in the top 5%. Risk increase depends on how you define "healthy." But the lifetime risk for BMI (18-25) is >10%. Seems like a fine definition for how most people perceive their health. 10% -> 20% (roughly)

      2 replies 0 retweets 0 likes
    7. Ali Torkamani‏ @ATorkamani 13 Mar 2019
      Replying to @ATorkamani @GidMK and

      I should note that the relative risk conveyed by these factors actually appears to be magnified in the healthy as well: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001647 … Which would lead to the surprising conclusion that you'd actually be underestimating risk in the healthy in this model.

      1 reply 0 retweets 0 likes
    8. Health Nerd‏Verified account @GidMK 13 Mar 2019
      Replying to @ATorkamani @cecilejanssens and

      The conclusion of that paper is that due to their low absolute risk, screening healthy younger participants is not advised

      1 reply 0 retweets 0 likes
    9. Ali Torkamani‏ @ATorkamani 13 Mar 2019
      Replying to @GidMK @cecilejanssens and

      Well - I think the issue is that you are mixing issues of public policy with personal choice. At least that is my view of the situation.

      1 reply 0 retweets 0 likes
    10. Health Nerd‏Verified account @GidMK 13 Mar 2019
      Replying to @ATorkamani @cecilejanssens and

      In what sense? Personal choice is wonderful language, but monitoring your diabetes status over a lifetime requires tens of thousands in lab tests, not to mention the cost of the test itself. Where's the value?

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 13 Mar 2019
      Replying to @GidMK @ATorkamani and

      But if we are going to talk public policy - as @statsepi noted above, it would be fascinating to see someone try and justify these tests based on an epidemiological argument

      4:24 PM - 13 Mar 2019
      1 reply 0 retweets 0 likes
        1. New conversation
        2. Ali Torkamani‏ @ATorkamani 13 Mar 2019
          Replying to @GidMK @cecilejanssens and

          Well - I certainly wouldn't be constantly monitoring my T2D status on the basis of these results. I'd think more like a short-term continuous glucose monitoring trial to see how you respond to different foods. Or just pass on dessert more often.

          1 reply 0 retweets 0 likes
        3. Health Nerd‏Verified account @GidMK 13 Mar 2019
          Replying to @ATorkamani @cecilejanssens and

          I have to say, I'm confused. Either the test is useful at giving you a meaningful prediction of your risk of diabetes - in which case you should absolutely actively monitor the situation - or it's not If you wouldn't make medical decisions based on the test, what's the point?

          0 replies 0 retweets 0 likes
        4. End of conversation

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