Myth: Genetic testing is a precise science that tells you disease risk, exercise optimization, and lineage Fact: Most genetic test results are very sketchy, built on vague regression models and the test results of white people
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Now, forgetting that both of the two studies in this paper had 50%+ dropout, and not ITT, this sentence is, uh, interesting They're saying that the p-values in the matched group were bigger, thus genetic matching works Not exactly best practicepic.twitter.com/wZds22pQR9
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If you look at the actual comparison between the two groups, there is some statistically significant improvement for the matched athletes, which makes that sentence even more confusingpic.twitter.com/HcQp5DlznX
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Also worth noting that these differences weren't in actual scores, they were in PERCENTAGE CHANGE. So genetic matching improved athletes' scores by about 5% more over 8 weeks of training
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So say you have two groups. Both start with a score of 10. What this would mean is that, after 8 weeks of this special training, one group scores 11 and the other one scores 10.95 Magic
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But even better, the groups WEREN'T RANDOM. This is actually brilliant, because it shows how finicky trials can be The study groups were randomized to two INTERVENTIONS - either high or low intensity training
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But the analysis variable is genetic testing. So actually what the researchers did was take their nice, randomized groups, and destroy them This is never mentioned in the study, but is a significant limitation
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Anyway, these are two of the BETTER genetic testing studies because at least they trialled some kind of intervention Mostly you just see a big predictive algorithm built on white guys and some fairy fluff
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It's amazing how much of genetic testing, outside of specific diseases and direct ancestry (parents, cousins etc) is just "hey look these genes correlate with that expression LET'S ASSUME CAUSATION THAT'S A GREAT IDEA"
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End of conversation
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