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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 6 Mar 2019

      Health Nerd Retweeted MabelR

      This is a common misconception that springs up all the time, so let's talk industry bias in scientific research Does industry funding make a study bad - a tweetorialhttps://twitter.com/mabelyang/status/1103491457854423040 …

      Health Nerd added,

      MabelR @mabelyang
      Replying to @GidMK
      You have omitted the important fact that the studies have been funded and backed by vaccine makers. Such studies can never be objective. Statens Serum Institut & Novo Nordisk make vaccines. #ConflictOfInterest
      3 replies 13 retweets 33 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK 6 Mar 2019

      The basic idea is similar to the one in the tweet above. You can find it anywhere Industry does research. But industry wants money. Therefore, their research is hopelessly biased, because they don't do research that doesn't earn them moneypic.twitter.com/dLyoXsLDoE

      1 reply 0 retweets 6 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK 6 Mar 2019

      The thing is, this isn't just a theoretical question. We can look at industry-funded trials and compare them to non-industry funded ones

      1 reply 0 retweets 6 likes
      Show this thread
      Health Nerd‏Verified account @GidMK 6 Mar 2019

      There are many ways of grading studies in terms of how "good" they are. One commonly-used (and in many ways gold standard) method is @cochranecollab risk of bias tool https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trials …pic.twitter.com/km9rxwiqex

      10:12 PM - 6 Mar 2019
      • 12 Likes
      • Woo detector #ARSE, Inventor of Fire Ella Flemyng Maria Thierry "Tex" Souccar 🧪✍📚🎨✈ MTL says please get vaxxed when you can! Take That, Medicine! The Cochrane Library bujaj49 Leesa 'soapy clean hands' Klich, MSc 🇨🇦
      1 reply 0 retweets 12 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK 6 Mar 2019

          Bias refers to elements that the study has failed to control for which may have influenced the outcome of the study For example, if the study had more dropouts in the intervention group, then it may have been biased

          1 reply 0 retweets 9 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK 6 Mar 2019

          So back to the original question Compared to non-industry trials, are industry trials (in terms of risk of bias)

          3 replies 0 retweets 4 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK 6 Mar 2019

          As I said, this is a question we can actually answer. Risk of bias is a somewhat subjective assessment, but even so we can compute it for different trials and see which ones are better or worse

          1 reply 0 retweets 7 likes
          Show this thread
        5. Health Nerd‏Verified account @GidMK 6 Mar 2019

          There are plenty of studies that have done just this Generally speaking, they find that industry funded trials are either as good as or BETTER than trials funded through other methods https://www.bmj.com/content/326/7400/1167?i- …pic.twitter.com/8eHxPMo1MZ

          1 reply 2 retweets 13 likes
          Show this thread
        6. Health Nerd‏Verified account @GidMK 6 Mar 2019

          So we know that industry funded trials are usually as good as or better than other research What does that mean for their results?

          1 reply 0 retweets 7 likes
          Show this thread
        7. Health Nerd‏Verified account @GidMK 6 Mar 2019

          To put it another way, are industry funded trials more or less likely to find positive results for the funding body?

          1 reply 1 retweet 2 likes
          Show this thread
        8. Health Nerd‏Verified account @GidMK 6 Mar 2019

          Well, we know that they're pretty good trials. If they were all fair comparisons, they should be the same or perhaps less likely

          1 reply 0 retweets 2 likes
          Show this thread
        9. Health Nerd‏Verified account @GidMK 6 Mar 2019

          But instead, when we look at the evidence, we find... Exactly the opposite Industry funded trials mostly report positive results for the funding bodypic.twitter.com/nblpNjJ564

          1 reply 0 retweets 7 likes
          Show this thread
        10. Health Nerd‏Verified account @GidMK 6 Mar 2019

          How can this be????

          1 reply 0 retweets 2 likes
          Show this thread
        11. Health Nerd‏Verified account @GidMK 6 Mar 2019

          (I'll give you a hint - the industry is definitely not always right)

          1 reply 0 retweets 2 likes
          Show this thread
        12. Health Nerd‏Verified account @GidMK 6 Mar 2019

          A few people have answered, so let's put the cards on the table That's right, it's publication bias!

          1 reply 0 retweets 6 likes
          Show this thread
        13. Health Nerd‏Verified account @GidMK 6 Mar 2019

          If we look at industry funded trials, they are almost never negative (i.e. no benefit for the funding body) It turns out that often, the negative trials just aren't published!

          4 replies 1 retweet 13 likes
          Show this thread
        14. Health Nerd‏Verified account @GidMK 6 Mar 2019

          So individual trials can be very good - meaning that industry funding isn't necessarily an issue for individual trials - but they still make a misleading picture overall

          2 replies 0 retweets 8 likes
          Show this thread
        15. Health Nerd‏Verified account @GidMK 6 Mar 2019

          If you're interested in this issue, you should follow @senseaboutsci who are doing great work getting studies registered and published

          2 replies 0 retweets 10 likes
          Show this thread
        16. Health Nerd‏Verified account @GidMK 6 Mar 2019

          So ultimately, saying "the industry funded this trial" doesn't necessarily mean much in terms of its quality What it does say is that you should be looking for more research overall because there may be unpublished work contradicting the findings

          5 replies 2 retweets 28 likes
          Show this thread
        17. End of conversation

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