Talking to a basic scientist about Registered Reports today. ‘It doesn’t work for basic science’ he said. ‘We get our data, *then* work out what story we can tell to get us into Nature’. No idea there might be anything wrong with that.
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I agree, but I’ve rarely seen an animal experiment that had a sample size based on a power analysis or meaningful effect size. Almost always the stuff listed above.
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This is listed, specifically, in the ARRIVE guidelines (10b): https://www.nc3rs.org.uk/sites/default/files/documents/Guidelines/NC3Rs%20ARRIVE%20Guidelines%20Checklist%20(fillable).pdf … A lot of journals that publish data from animal studies say they adhere to these guidelines. Problem is editors do not check for this.
End of conversation
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Yes! Scientists always say to me ‘we can only use three animals for ethical reasons,’ not getting that it is completely unethical to do a study that will yield no information.
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