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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019

      (THREAD) misleading results from subgroup analysis combined with regression to the mean in crossover RCT’s. Pull up a chair, let’s have a chat.pic.twitter.com/jA86IV1CRD

      7 replies 51 retweets 141 likes
      Show this thread
    2. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019

      Credit to @Srpatelmd for spotting this:https://www.ncbi.nlm.nih.gov/pubmed/30395486 

      1 reply 0 retweets 4 likes
      Show this thread
    3. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019

      This is a crossover RCT of 20 sleep apnea patients comparing one night of atomoxetine 80mg plus oxybutynin 5mg (ato-oxy) versus placebo administered prior to sleep

      1 reply 0 retweets 0 likes
      Show this thread
    4. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019

      Primary outcome: apnea hypopnea index (AHI), continuous variable. Higher AHI = more severe sleep apnea.

      1 reply 0 retweets 0 likes
      Show this thread
    5. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019

      In an effort to show that ato-oxy was *especially* effective in the patients with more severe sleep apnea, the authors included the following subgroup analysis:

      1 reply 0 retweets 0 likes
      Show this thread
    6. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019

      “When analysis was limited to the 15 patients with OSA (AHI≥10 events/h) on placebo, ato-oxy reduced AHI by approximately 28 events/h or 74%”

      2 replies 0 retweets 0 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK 27 Feb 2019
      Replying to @ADAlthousePhD

      I'm confused. Unless I'm mistaken, that's not the definition of OSA. Could this perhaps be a bit of selective data slicing?pic.twitter.com/JLorPwQRUk

      1 reply 0 retweets 0 likes
    8. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019
      Replying to @GidMK

      I don’t think it’s quite that nefarious. I just don’t think the authors really get why what they did introduces such a bias.

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 27 Feb 2019
      Replying to @ADAlthousePhD

      Fair enough. It's just a weird definition of OSA as far as I'm aware, usually you'd go with either 5 or 15

      5:11 PM - 27 Feb 2019
      • 1 Like
      • Andrew Althouse
      1 reply 0 retweets 1 like
        1. Andrew Althouse‏ @ADAlthousePhD 27 Feb 2019
          Replying to @GidMK

          The overall results of the trial were positive before even doing the subgroup analysis. There’s enough here to move forward to larger confirmatory trial. I’m just sighing that nobody pointed out how dumb (and unnecessary!) this subgroup analysis was/is.

          0 replies 0 retweets 1 like
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