This is brilliant. Modifying an intention-to-treat approach makes it...not an intention-to-treat approach. The study didn't even report the number of missing values!pic.twitter.com/h4z3Y8ZJti
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The specific methods section you have screenshotted looks problematic for several reasons (LOCF?!) but mITT can have a legitimate role, depending on how / why the mITT is defined.
Yeh the LOCF part was also very worrying, and they didn't really report what their mITT was. The rest of the study wasn't great either unsurprisingly
Well, since there are missing outcomes, a strict ITT analysis is not possible. Whether not imputing values for patients not contributing any post-rand data (their mITT) is reasonable for the claims investigated depends on the situation. (As always with missing data).
My understanding was that a strict ITT in this case would be to exclude missing values from the analysis? I guess it depends on how many values were missing (which was not reported)
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