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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. David Grainger‏ @sciencescanner 13 Nov 2018

      David Grainger Retweeted Adrian H

      Absolutely. Same point for $AMRN as for $NVS Entresto. By using the “wrong” comparitor, they generate positive data but leave unanswered questionshttps://twitter.com/Adrian_H/status/1062473481860931584 …

      David Grainger added,

      Adrian H @Adrian_H
      Replying to @sciencescanner @ideapharma @JohnCendpts
      It would’ve been very interesting if they’d also had a fish oil arm as a placebo (without trying to get to super high EPA doses)
      7 replies 1 retweet 21 likes
    2. Health Nerd‏Verified account @GidMK 13 Nov 2018
      Replying to @sciencescanner @matthewherper

      I'm also interested in the cost-effectiveness, based on the cost of Vascepa and the NNT (21 events prevented/5 patient-years) it looks like ~$315,000 per averted event even if the mineral oil didn't skew the results

      1 reply 0 retweets 0 likes
    3. sharinky‏ @SharonAConklin 13 Nov 2018
      Replying to @GidMK @sciencescanner @matthewherper

      63,000 per event prevented.

      1 reply 0 retweets 0 likes
    4. Health Nerd‏Verified account @GidMK 13 Nov 2018
      Replying to @SharonAConklin @sciencescanner @matthewherper

      How so? By my calculations, based on a 5-year NNT of 21, and a monthly cost of $250 (averaged from a few online stores) for the 4g daily dose cited in the study, it would be 12*250*5*21 = $315,000 My cost for Vascepa could, of course, be incorrect, is it cheaper?

      1 reply 0 retweets 0 likes
    5. sharinky‏ @SharonAConklin 13 Nov 2018
      Replying to @GidMK @sciencescanner @matthewherper

      It is my understanding It's not a 5 year calculation, the NNT calculation is an annual amount.

      1 reply 0 retweets 0 likes
    6. Health Nerd‏Verified account @GidMK 13 Nov 2018
      Replying to @SharonAConklin @sciencescanner @matthewherper

      Unless I'm wildly misreading the study, the NNT was based on a 5% absolute reduction over the course of the 5 years, and was not annualizedpic.twitter.com/Y9xuywcKvN

      1 reply 0 retweets 0 likes
    7. sharinky‏ @SharonAConklin 13 Nov 2018
      Replying to @GidMK @sciencescanner @matthewherper

      Ok on the five year. On another note, the amount per script might be closer to gross revenue than net revenue. After insurance discounts, I would say closer to $210.

      1 reply 0 retweets 0 likes
    8. Health Nerd‏Verified account @GidMK 13 Nov 2018
      Replying to @SharonAConklin @sciencescanner @matthewherper

      Fair enough. That puts the cost per averted event at ~$260,000, which is still around 2.5x the willingness to pay threshold

      1 reply 0 retweets 0 likes
    9. sharinky‏ @SharonAConklin 13 Nov 2018
      Replying to @GidMK @sciencescanner @matthewherper

      It's late, but isn't willingness to pay an annual amount?

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 13 Nov 2018
      Replying to @SharonAConklin @sciencescanner @matthewherper

      Mmmm but the cost to prevent an event is fixed, it doesn't need annualization. If you gave Vascepa to 105 people, you'd expect 5 events prevented over 5 years at a cost of $315,000 per event, or 1 event prevented over 1 year for the same cost

      9:03 PM - 13 Nov 2018
      0 replies 0 retweets 0 likes

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