We have evidence for the harmful effects of NSAIDs https://www.telegraph.co.uk/science/2017/05/09/one-week-painkillers-can-increase-chances-heart-attack-new-study/ …
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And study that shows Curcumin Works as well as ibuprofen “people taking 2 grams of phytosomal curcumin (called Meriva) had pain reduction equivalent to 800 mg of ibuprofen.” https://www.ncbi.nlm.nih.gov/pubmed/19678780
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Important to be clear on the full picture of NSAIDs in OA: - definitely better pain relief than placebo in short-term - no evidence of any long-term improvement in disease course - thrown in you get up to 30% increased risk of major cardiovascular event + ulcers etc
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Also don’t forget the potential ototoxic effects of NSAIDs.
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