Key take-homes from this meta of LC for diabetes: 1. Low-carb had a very modest benefit at 6 mo and 1 yr 2. No benefit to low carb or low fat at 2 yr 3. Evidence is pretty bad quality all round so anyone making definitive statements is probably wronghttps://twitter.com/whsource/status/1044330859741020162 …
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The physiological changes that occur in the mitochondria and downstream when a diet is ketogenic are measurable and myriad. There is an enormous literature. Many mechanisms are understood. Hard to choose just one, but see this review (over a decade old): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/ …
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"there is evidence from uncontrolled clinical trials and studies in animal models" sounds like a plausible mechanism rather than demonstrable fact
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