This is actually one of the first examples of a study that I really couldn't see much of a reason for
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Open to manipulation via the methodology of the trial that for May of the original statin trials excluded all individuals with side effects
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*many
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Also I dispute the proxy measures used to determine cardiovascular risk in statin trials too short to follow up cardiac events and all cause mortality. When they do follow up for long enough NNT rates look ridiculous to me .And a lot of experts agree with me .
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This is, as I said, true for low-risk. There is very little/no debate about high-risk individuals, because the NNT goes down enormously. That's kinda the point I was making
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