Also re: "The C is for controlled"...so what? You can have highly controlled trials that address pragmatic concerns, and totally uncontrolled trials that have little to do with the real world Pragmatism and control are not two ends of a spectrum
I am again confused. Obviously we care about the outcomes, the point is that grade C evidence can be applied to a diverse range of settings because it is an assessment of evidential backing
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You and me both buddy! So if an intervention isn’t achieving its objective (eg ADG, Grade C) “just keep going bc Grade C is a good as we are ever going to get”?
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Grade C? So you have a large, well-conducted systematic review of similarly rigorous observational trials demonstrating that populations with ADG are worse off than populations without? I'd be fascinated to see it. Seriously, sounds like an amazing study
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