I'm not 100% with this. The RCTs can be done, and it can be done with GCP, but nobody wants to pay for. This is often a reason nutritional epi is the fallback, it is easier, which is not always a strong justification... https://twitter.com/NutritionWonk/status/1032967027185606656 …
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Replying to @NutritionWonk
I think the key here is triage of the important vs non-important questions. Some peoples questions are not making the cut. What to RCT, don't RCT something that we know from prelim data is likely to have tiny effects
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Replying to @DylanMacKayPhD @NutritionWonk
Do something like guidelines (some kind of WHO/MedDiet ish vs standard care (which I think is currently letting people do whatever they want). Or Low carb (30% or less ) vs 50 to 60% in type 2 diabetes. I bet the second one gets stopped early. Hard outcomes
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Replying to @NutritionWonk @DylanMacKayPhD
I'd also like to see more study on what, why, and how diets works best for individuals, rather than just randomizing people to diets that on average don't work much for anyone.
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Also, more mixed methods diet RCTs with qualitative data. I want to know what people thought of the diets and what their experience was like.
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Or rcts that include analysis of the lived environment and cultural experiences that inform eating in the real world
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