The steps of a failed pet intervention: 1. Interesting theory 2. Promising rodent results 3. Encouraging small trials 4. Discouraging large trials 5. Depressing systematic review(s) 6. Theory dead 7. No 8. IT WORKED IN RATS 9. YOU WON'T CRUSH MY HOPE 10. THEORY WILL NEVER DIE
If there's been a systematic review that found 10 high-quality RCTs which included 10,000 participants that found no benefit from your intervention, to me that is MUCH stronger evidence than a study in 40 rats
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@cochranecollab has reviewed the question and found that there is likely no benefit, that's a whole lot better than a study in MCF-7 cancer cellsShow this threadThanks. Twitter will use this to make your timeline better. UndoUndo
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