Oped arguing that the Human Genome Project was a dud. I don't fully agree, but I do agree that a sequence of nucleotides on its own is not enough & there hasn't been as much short-term fruit as was widely hoped.https://www.dallasnews.com/opinion/commentary/2019/10/13/was-the-human-genome-project-a-dud/ …
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The real question is do we double down with other omics (epigenomics, proteomics, microbiomics, etc.) or do we assume that all off this is nonsense, and if there were big effects (and targets) they would have been discovered by traditional science?
concordance rates and heritability show how important genes are; they don’t say how many genes have to interact to yield those effects. it’s not nonsense; it’s epistatic.
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That's why I said "targets". Can't design a drug to hit fifty genetic loci. I mean, genetics is obviously responsible for a ton of our adult health problems. But genomics from thgp onwards hasn't solved much. Any reason to expect other omics will?
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If I may: assuming “targets” as drug “targets” that might fit into drug discovery & dev pipeline, partly yes. Omics integrated w/ proper statistical & mathematical model + histology + clinical data can give causal mechanisms if we can establish genotype to phenotype relation.
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