"The fact that most of our major diseases, including schizophrenia and depression, are not as genetic in origin as previously thought should be regarded as good news." So the Genome project has proven psych assumptions wrong. That's scientific progress, isn't it?
Oped arguing that the Human Genome Project was a dud. I don't fully agree, but I do agree that a sequence of nucleotides on its own is not enough & there hasn't been as much short-term fruit as was widely hoped.https://www.dallasnews.com/opinion/commentary/2019/10/13/was-the-human-genome-project-a-dud/ …
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i don’t think it has actually shown that. what it has shown is that epistasis is hard.
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I've always found the majority of senior genomics researchers are in strong agreement (that it has all been a disappointment). I personally feel like we learned a lot about the problems with analysing massive datasets with tens of thousands of variables, and that is valuable.
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The real question is do we double down with other omics (epigenomics, proteomics, microbiomics, etc.) or do we assume that all off this is nonsense, and if there were big effects (and targets) they would have been discovered by traditional science?
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Few people who know what it takes to develop new medicines ever thought there would be massive short-term clinical impact from the HGP. The HGP was a *start point* for genomic medicine not an *end point*. Was the HGP overhyped by some prominent geneticists and media? For sure.
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