One fact supporting critical gender theory is that there is no single attribute exclusive to all members of a biological sex. Not all born-men have penises, for instance, or the same male genes, or even XY karyotypes (cf. de la Chapelle syndrome). Sex, then, is a ship of Theseus.
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Like I said, it's mostly anisogamy. Unless I'm mistaken, before any medical transition takes place, most trans people are fertile and make normal gametes of their biological sex. They are trans specifically because their gender identity does not match their biological sex.
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So the line is mostly around conditions that result in the inability to make functional gametes. This is mostly intersex conditions, though I guess that something like transgenderism could be included. Atc which point designation of "sex" is more of a social issue.
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