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First the chromatin opens, then the DNA methylation is lost. The chromatin opens because transcription factors (TFs) target those loci. TFs tell DNA methylation and nucleosomes what to do at cis-regulatory loci. Not the other way around. Your textbook needs a rewrite.https://twitter.com/molecularcell/status/1222548588930011137 …
And yet targeted methylation and demethylation assays can have sustained impacts on transcription level. Causality can be in both directions.https://pubmed.ncbi.nlm.nih.gov/31724704-harnessing-targeted-dna-methylation-and-demethylation-using-dcas9/ …
Here’s the challenge — find a textbook that says *anything at all* about DNA methylation being regulated by TFs. Yes, it can work both ways. But the changes we are most interested in are probably TF-driven. And the textbooks only talk about DNA methylation regulating TF binding.
Ummm, WT1 and TET2?!
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