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A new paper from our lab: Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice https://cell.com/neuron/fulltext/S0896-6273(19)30886-4#.XdLGrZ-yK6s.twitter … If you're interested, there's a short thread below 1/n
Memory formation is associated with enduring changes in neural circuits. A traditional (neurocentric) view is that these changes reflect modifications in synaptic connectivity.
This work was led by @PESteadman.
2/npic.twitter.com/o0YM7mBcbl
However, the speed of conduction along axons may also impact neural circuit function, and previous work has established that neural activity produces persistent changes in axon myelination. 3/n
Here, we wanted to ask whether such white matter plasticity* is critical for consolidation of hippocampus-dependent memories. * White matter plasticity might involve changes in existing myelin or de novo myelination. We focused on the latter. 4/n
In mice*, we found that spatial learning (in the water maze) induced oligodendrogenesis and de novo myelination in task relevant circuits. Critically, blocking these changes impaired consolidation of spatial and contextual fear memories.
* Yes, don't @justsaysinmice me
5/npic.twitter.com/YdoRuFsdhj
Successful consolidation of contextual memories is associated with increased coupling of hippocampal ripples and cortical spindles. We found that consolidation-associated increases in ripple-spindle coupling was prevented when we blocked oligodendrogenesis. 6/npic.twitter.com/dS9cDyPsj6
And, in the same mice, contextual fear memory consolidation was impaired. 7/npic.twitter.com/eulsHI8THt
Bottom line: We think these data provide evidence for the idea that adult oligodendrogenesis plays a key role in memory consolidation, most likely via fine-tuning myelin patterns to promote hippocampal-cortical communication following learning. 8/npic.twitter.com/u8LGIOoeu8
An aside: About 10 years ago I gave a seminar at NIH and I had an great one-on-one meeting with Doug Fields. The discussion we had there provided the inspiration for these experiments. After a couple of false starts, we finally got there 10 years on. Thanks Doug! 9/n
Patrick and I thank our collaborators on twitter: @F_Xia_, @SteenlandNT , @michelle_monje and @sjo09 (and of course our twitterless collaborators too).
As soon as I get the free pdf link, I will post it here.
10/n
Great work Paul, Congrats!!
Thanks, Roberto!
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