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Incrimination of convalescent plasma for promoting functional escape #SARSCoV2 variants, including a key one (E484) of the South Africa variant
https://www.biorxiv.org/content/10.1101/2020.12.31.425021v1.full.pdf … @jbloom_lab
A great
goes through the details and significance
https://twitter.com/jbloom_lab/status/1346442000472580098 …pic.twitter.com/VoVeMTWHqW
Relevant concerns about resistance to polyclonal antibodies of the E484K aptly summarized by @AliNouriPhDhttps://twitter.com/AliNouriPhD/status/1346482201119125505 …
BREAKING on pic.twitter.com/E1bXcnDKtu
@DrEricDing do you have anything to add here?
Elegant work but concerning conclusions. Worth repeating with polyclonal abs from vaccine recipients. Also, some fairly straight forward mathematical modelling could estimate likelihood of emergence of vaccine resistant strains as a function of mutation rate, viral prevalence.
An E484K variant means that a negatively charged spot on the spike protein is now positively charged. So antibodies that use the negative charge to help the interaction will now be repelled.
Have you read this One? Three mutations to escape https://www.biorxiv.org/content/10.1101/2020.12.28.424451v1.full.pdf …
it would be mad to give 1 dose or two 1/2 dose vaccines with this variant about
Longer it takes to crush Covid, the more time Sars-Cov-2 virus has to evolve adaptive mutations.
Can someone explain this in layman’s terms?? Thanks.
E484K is an electrostatic charge reversal, does it significantly affect binding to substrates other than antibodies, or overall function?
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