There is ample evidence that presymptomatic people commonly infect others, like this one @NatureMedicine
https://www.nature.com/articles/s41591-020-0869-5 … by @gmleunghku and @hkumed colleaguespic.twitter.com/VosN44CCI3
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There is ample evidence that presymptomatic people commonly infect others, like this one @NatureMedicine
https://www.nature.com/articles/s41591-020-0869-5 … by @gmleunghku and @hkumed colleaguespic.twitter.com/VosN44CCI3
Our @AnnalsofIM paper zoomed in on 16 cohorts to partition the presymptomatics vs asymptomatics, which was done by serial assessment in many of these reports
https://www.acpjournals.org/doi/10.7326/M20-3012 …
and making a conservative estimate that ~40-45% of infected people don't (ever) develop symptomspic.twitter.com/TptCxmmFCm
But the whether the people in this asymptomatic category (Asx) spread like those who have symptoms (or pre-symptomatics) is not determined. We only know the viral loads are similar from multiple reports. And we do know some spread occurs from ASx people.
To provide meaningful data on the magnitude of transmissibility from asymptomatic people a prospective study would need to be done to quantify spread & ideally include: —contact tracing, forward and backward —culture of the virus —virus genomic sequence to precisely define route
The rest of the relevant points were addressed in a recent threadhttps://twitter.com/EricTopol/status/1269359663591510016 …
WHO is confusing and elevating risks
People looking for conspiracy theories will now claim the W.H.O. can't get their story straight. Good job W.H.O.!
Key point for general public: at the time of contact, you cannot ascertain whether someone is pre-symptomatic or asymptomatic. Therefore, your behavior should be the same! #socialdistancing #wearmasks
This distinction is the most important piece of information in processing what the WHO said today.
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